Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
BOYLE J DAVID II
   2. Issuer Name and Ticker or Trading Symbol
AVI BIOPHARMA INC [AVII] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
CFO
(Last)
(First)
(Middle)
4575 SW RESEARCH WAY, SUITE 200		 3. Date of Earliest Transaction (Month/Day/Year)
03/09/2010
(Street)

CORVALLIS, OR 97333		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock               65,282 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Incentive Stock Option (right to buy) $ 1.3 03/09/2010   A   10,000   03/09/2011(1) 03/09/2020 Common Stock 10,000 $ 0 (2) 10,000 D  
Non-Qualified Stock Option (right to buy) $ 1.3 03/09/2010   A   90,000   03/09/2011(1) 03/09/2020 Common Stock 90,000 $ 0 (2) 90,000 D  
Incentive Stock Option (right to buy) $ 0.92             02/10/2010(1) 02/10/2019 Common Stock 50,000   50,000 D  
Incentive Stock Option (right to buy) $ 1.21             08/18/2008(3) 08/18/2018 Common Stock 247,932   247,932 D  
Incentive Stock Option (right to buy) $ 1.45             02/09/2011(1) 02/09/2020 Common Stock 97,241   97,241 D  
Non-Qualified Stock Option (right to buy) $ 0.92             02/10/2010(1) 02/10/2019 Common Stock 100,000   100,000 D  
Non-Qualified Stock Option (right to buy) $ 1.21             08/18/2008(3) 08/18/2018 Common Stock 102,068   102,068 D  
Non-Qualified Stock Option (right to buy) $ 1.45             02/09/2011(1) 02/09/2020 Common Stock 82,759   82,759 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
BOYLE J DAVID II
4575 SW RESEARCH WAY, SUITE 200
CORVALLIS, OR 97333		       CFO  

Signatures

 John David Boyle II   03/10/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The Stock Option Grant vest as follows: 1/3 vest one year from date of grant and 1/3 each year thereafter until all shares vest three years from grant date.
(2) Price not required on initial report of stock option granted.
(3) The options vest in equal annual installments over three years beginning on August 18, 2008.

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