UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                                November 7, 2006

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
               (state or other juris- (Commission (I.R.S. Employer
           diction of incorporation) File Number) (Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080


          (Former name or former address, if changed since last report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12) [ ] Pre-commencement  communications pursuant to Rule 14d-2(b) under
the Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))






Section 4 - Matters Related to Accountants and Financial Statements

Item 4.01 Changes in The Registrant's Certifying Accountant.

Retention of New Accountants

         On  November 7, 2006,  the Audit  Committee  of our Board of  Directors
approved  the  appointment  of  McGladrey & Pullen,  LLP ("  McGladrey")  as our
independent registered public accounting firm, effective immediately.  McGladrey
replaces BDO as our independent registered public accounting firm.

         During our two most recent  fiscal  years ended  December  31, 2004 and
December 31,  2005,  and through the date of this Report on Form 8-K, we did not
consult McGladrey with respect to the application of accounting  principles to a
specified  transaction,  either  completed  or  proposed,  or the  type of audit
opinion that might be rendered on our financial statements, or any other matters
or reportable events listed in Items 304(a)(2) of Regulation S-K.

Resignation of Former Accountants

         As noted in our Current  Report on Form 8-K/A filed with the Commission
on September 22, 2006, BDO Seidman, LLP ("BDO") informed us that it would resign
from  the  client-auditor  relationship  with us no  later  than the date of our
filing of our Form 10-Q report for the period ending  September 30, 2006.  BDO's
decision to resign was not  recommended or approved by our Audit  Committee.  On
November 7, 2006,  we filed our Form 10-Q report for the period ended  September
30, 2006 and BDO resigned from the client-auditor relationship with us.

         BDO's  reports on our financial  statements  for the fiscal years ended
December 31, 2004 and  December 31, 2005 did not contain any adverse  opinion or
any disclaimer of opinion and were not qualified or modified as to  uncertainty,
audit scope or accounting principles.

         During the fiscal years ended  December 31, 2004 and December 31, 2005,
and the subsequent interim period preceding the date of BDO's resignation, there
were no disagreements  between us and BDO on any matter of accounting principals
or  practice,  financial  statement  disclosure  or auditing  scope of procedure
which, if not resolved to the satisfaction of BDO, would have caused BDO to make
a reference to the subject  matter  thereof in connection  with its reports and,
during  the same  period,  there  were no  reportable  events as defined in item
304(a)(1)(v) of the Commission  Regulation S-K, except as previously reported in
Item 9A of our 2005 Form 10-K/A2.

         We provided  BDO with a copy of this  Report on Form 8-K and  requested
that BDO furnish us with a letter addressed to the SEC stating whether it agrees
with the foregoing  statements by us and, if not,  stating the respects in which
it does not agree. A copy of the letter from BDO stating that it does agree with
the foregoing statements is filed with this Report on Form 8-K as Exhibit 16.1.

On November 9, 2006,  Hemispherx issued a press release disclosing the retention
of McGladrey & Pullen, LLP, a copy of which is attached hereto as Exhibit 99.1.

Section 9 - Financial Statements and Exhibits Item 9.01 Financial Statements and
Exhibits.

(c)      Exhibits


Exhibit No.                Description

16.1     Letter on change in certifying accountant.
99.1     Press Release dated November 9, 2006.








                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                HEMISPHERX BIOPHARMA, INC.


November 9, 2006              By:  /s/ Robert Peterson
                                --------------------------------------------
                                Robert Peterson, Chief Financial Officer