Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
THOMAS MCNERNEY & PARTNERS LP
  2. Issuer Name and Ticker or Trading Symbol
ZOGENIX, INC. [ZGNX]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
_____ Officer (give title below) __X__ Other (specify below)
See Footnote (10)
(Last)
(First)
(Middle)
60 SOUTH 6TH STREET, SUITE 3620
3. Date of Earliest Transaction (Month/Day/Year)
11/29/2010
(Street)

MINNEAPOLIS, MN 55402
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 11/29/2010   C   1,152,780 A (1) 1,152,780 D (2) (9) (10)  
Common Stock 11/29/2010   C   207,159 A (1) 1,359,939 D (2) (9) (10)  
Common Stock 11/29/2010   C(3)   129,855 A (3) 1,489,794 D (2) (9) (10)  
Common Stock 11/29/2010   P   173,399 A $ 4 1,663,193 D (2) (9) (10)  
Common Stock 11/29/2010   C   42,840 A (1) 42,840 I (4) (9) (10) By TMP Nominee, LLC
Common Stock 11/29/2010   C   7,697 A (1) 50,537 I (4) (9) (10) By TMP Nominee, LLC
Common Stock 11/29/2010   C(3)   2,379 A (3) 52,916 I (4) (9) (10) By TMP Nominee, LLC
Common Stock 11/29/2010   P   3,178 A $ 4 56,094 I (4) (9) (10) By TMP Nominee, LLC
Common Stock 11/29/2010   C   4,380 A (1) 4,380 I (5) (9) (10) By TMP Associates, L.P.
Common Stock 11/29/2010   C   786 A (1) 5,166 I (5) (9) (10) By TMP Associates, L.P.
Common Stock 11/29/2010   C(3)   484 A (3) 5,650 I (5) (9) (10) By TMP Associates, L.P.
Common Stock 11/29/2010   P   647 A $ 4 6,297 I (5) (9) (10) By TMP Associates, L.P.

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A-1 Convertible Preferred Stock (1) 11/29/2010   C     11,527,800   (1)   (1) Common Stock 1,152,780 (1) 0 D (2) (9) (10)  
Series B Convertible Preferred Stock (1) 11/29/2010   C     2,071,593   (1)   (1) Common Stock 207,159 (1) 0 D (2) (9) (10)  
8% Convertible Promissory Note (3) 11/29/2010   C(3)     129,855   (3)   (3) Common Stock 129,855 (3) 0 D (2) (9) (10)  
Series A-1 Convertible Preferred Stock (1) 11/29/2010   C     428,400   (1)   (1) Common Stock 42,840 (1) 0 I (4) (9) (10) By TMP Nominee, LLC
Series B Convertible Preferred Stock (1) 11/29/2010   C     76,975   (1)   (1) Common Stock 7,697 (1) 0 I (4) (9) (10) By TMP Nominee, LLC
8% Convertible Promissory Note (3) 11/29/2010   C(3)     2,379   (3)   (3) Common Stock 2,379 (3) 0 I (4) (9) (10) By TMP Nominee, LLC
Series A-1 Convertible Preferred Stock (1) 11/29/2010   C     43,800   (1)   (1) Common Stock 4,380 (1) 0 I (5) (9) (10) By TMP Associates, L.P.
Series B Convertible Preferred Stock (1) 11/29/2010   C     7,869   (1)   (1) Common Stock 786 (1) 0 I (5) (9) (10) By TMP Associates, L.P.
8% Convertible Promissory Note (3) 11/29/2010   C(3)     484   (3)   (3) Common Stock 484 (3) 0 I (5) (9) (10) By TMP Associates, L.P.

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
THOMAS MCNERNEY & PARTNERS LP
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
Thomas, McNerney & Partners, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
TMP Nominee, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
TMP ASSOCIATES LP
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
Thomas, McNerney & Partners II L.P.
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
Thomas, McNerney & Partners II, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
TMP Nominee II, LLC
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
TMP Associates II LP
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
THOMAS JAMES E
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)
McNerney Pete
60 SOUTH 6TH STREET
SUITE 3620
MINNEAPOLIS, MN 55402
      See Footnote (10)

Signatures

 /s/ James E. Thomas, Manager of Thomas, McNerney & Partners, LLC, the general partner of Thomas, McNerney & Partners, L.P.   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of Thomas, McNerney & Partners, LLC   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of TMP Nominee, LLC   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of Thomas, McNerney & Partners, LLC, the general partner of TMP Associates, L.P.   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of Thomas, McNerney & Partners II, LLC, the general partner of Thomas, McNerney & Partners II, L.P.   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of Thomas, McNerney & Partners II, LLC   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of TMP Nominee II, LLC   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas, Manager of Thomas, McNerney & Partners II, LLC, the general partner of TMP Associates II, L.P.   11/29/2010
**Signature of Reporting Person Date

 /s/ James E. Thomas   11/29/2010
**Signature of Reporting Person Date

 /s/ Peter H. McNerney   11/29/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each of the Series A-1 Convertible Preferred Stock and the Series B Convertible Preferred Stock automatically converted to Common Stock at the closing of the Issuer's initial public offering on November 29, 2010 at a conversion ratio one share of Common Stock for every ten shares of Series A-1 Convertible Preferred Stock and one share of Common Stock for every ten shares of Series B Convertible Preferred Stock, as applicable, rounded down to the next whole number, for no additional consideration.
(2) These securities are owned of record by Thomas, McNerney & Partners, L.P. ("TMP LP"). Thomas, McNerney & Partners, LLC ("TMP LLC") is the general partner of TMP LP and has shared voting and dispositive power of the securities held by TMP LP, but TMP LLC disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein. The managers of TMP LLC having shared voting and dispositive power over these securities are James E. Thomas and Peter H. McNerney, each of whom disclaims beneficial ownership of such shares except to the extent of their pecuniary interest therein.
(3) The principle of the Note and accrued interest thereon was automatically converted upon the closing of the Issuer's initial public offering on November 29, 2010 into shares of Common Stock at a conversion price equal to $4.00 per share, the per share price of the Common Stock sold in the Issuer's initial public offering.
(4) These securities are owned of record by TMP Nominee, LLC ("TMP Nominee"). The managers of TMP Nominee having shared voting and dispositive power over these securities are James E. Thomas and Peter H. McNerney, each of whom disclaims beneficial ownership of such shares except to the extent of their pecuniary interest therein.
(5) These securities are owned of record by TMP Associates, L.P. ("TMP Associates"). TMP LLC is the general partner of TMP Associates and has shared voting and dispositive power of the securities held by TMP Associates, but TMP LLC disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein. The managers of TMP LLC having shared voting and dispositive power over these securities are James E. Thomas and Peter H. McNerney, each of whom disclaims beneficial ownership of such shares except to the extent of their pecuniary interest therein.
(9) The filing of this statement shall not be deemed an admission that, for the purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the Reporting Persons are the beneficial owners of equity securities covered by this statement.
(10) Upon the closing of the Issuer's initial public offering on November 29, 2010, the Reporting Persons ceased to be 10% owners of the Issuer's securities.
 
Remarks:
Because of the limitations on the number of line-item holdings that can be filed on any one Form 4 through the SEC's EDGAR system, the reporting persons have filed two (2) Form 4's with respect to Zogenix, Inc. on the date hereof, which, taken together, constitute one Form 4. The Reporting Person named in Box 1 of these three Form 4's is Thomas, McNerney & Partners, L.P.  This Form 4 is filed as Part 1 of 2 parts.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.