Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
GARNER CAM L
   2. Issuer Name and Ticker or Trading Symbol
ZOGENIX, INC. [ZGNX] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O ZOGENIX, INC., 5858 HORTON STREET, SUITE 455		 3. Date of Earliest Transaction (Month/Day/Year)
02/12/2019
(Street)

EMERYVILLE, CA 94608		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 02/12/2019   M   218 A $ 32 218 D  
Common Stock 02/12/2019   M   1,562 A $ 30.96 1,780 D  
Common Stock 02/12/2019   M   6,250 A $ 15.04 8,030 D  
Common Stock 02/12/2019   M   4,375 A $ 14.88 12,405 D  
Common Stock 02/12/2019   S   12,405 D (1) $ 46.8478 (2) 0 D  
Common Stock               40,843 I By Garner Investments, LLC (3)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 32 02/12/2019   M     218   (4) 05/29/2020 Common Stock 218 $ 0 0 D  
Stock Option (Right to Buy) $ 30.96 02/12/2019   M     1,562   (5) 05/23/2021 Common Stock 1,562 $ 0 0 D  
Stock Option (Right to Buy) $ 15.04 02/12/2019   M     6,250   (6) 04/26/2022 Common Stock 6,250 $ 0 0 D  
Stock Option (Right to Buy) $ 14.88 02/12/2019   M     4,375   (7) 06/05/2022 Common Stock 4,375 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
GARNER CAM L
C/O ZOGENIX, INC.
5858 HORTON STREET, SUITE 455
EMERYVILLE, CA 94608		   X      

Signatures

 /s/ Thomas Doyle, Attorney-in-fact for Cam L. Garner   02/14/2019
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The exercise and sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan.
(2) The price reported in Column 4 is a weighted average price.These shares were sold in multiple transactions at prices ranging from $46.31 to $47.19, inclusive.The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, additional information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(3) The Reporting Person is the managing member of Garner Investments, LLC.
(4) The Option was granted on May 30, 2010 and vests in a series of twelve (12) successive, equal monthly installments beginning on the date of grant, subject to the Reporting Person's continued service to the Company on each vesting date.
(5) The Option was granted on May 24, 2011 and vests in a series of twelve (12) successive, equal monthly installments beginning on the date of grant, subject to the Reporting Person's continued service to the Company on each vesting date.
(6) The Option was granted on April 27, 2012 and vests in a series of thirty-six (36) successive, equal monthly installments beginning on the date of grant, subject to the Reporting Person's continued service to the Company on each vesting date.
(7) The Option was granted on June 6, 2012 and vests in a series of twelve (12) successive, equal monthly installments beginning on the date of grant, subject to the Reporting Person's continued service to the Company on each vesting date.

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