Former NFL running back O.J. Simpson has passed away, according to his family. He was 76.

"On April 10th, our father, Orenthal James Simpson, succumbed to his battle with cancer," they wrote on X.

He died surrounded by his children and grandchildren, they said. 

His bout with cancer was mostly kept from the public. 

O.J. SIMPSON MURDER TRIAL PROSECUTOR RECEIVES SUPPORT FROM JUDGE ON JUDICIAL CAMPAIGN

"During this time of transition, his family asks that you please respect their wishes for privacy and grace," the statement added.

Simpson was widely regarded as a legendary running back — and perhaps one of the best running backs of all time — but his fame was eclipsed by the double murder trial of his ex-wife and her friend.

He became embroiled in a murder trial following a June 1994 arrest in connection with the brutal slayings of ex-wife Nicole Brown Simpson and her friend, Ron Goldman. Simpson was 46 years old at the time.

On June 21, 1994, Simpson was arraigned and pleaded not guilty. 

His status as an accused double murderer rocked the country and his courtroom trials captivated households. His fall from grace continued throughout the mid-90s and early 2000s.

That murder case, dubbed "The Trial of the Century," received international press attention and was recently dramatized in the popular TV show, "The People v. O.J. Simpson." It was also examined in the 2016 documentary, "OJ: Made in America."

The case's enormous popularity stemmed from Simpson's fame and whether he was innocent — or whether he was guilty and he got away with it.

A glove was recovered at the scene but DNA evidence was relatively unknown technology at the time. Simpson's lawyer, Johnnie Cochran Jr., famously proclaimed that if the glove "doesn't fit, you must acquit." 

The trial ended on October 3, 1995, when he was acquitted in the 1994 murders. 

The acquittal came nine months after the trial began — or about 16 months after Brown Simpson and Goldman were found murdered outside her home in Los Angeles.

After Simpson was found not guilty, the Goldman and Brown families sued Simpson in civil court, alleging wrongful death.

The civil trial began in October 1996 and Simpson was later found to be responsible for the deaths.

His legal problems continued years later when he was arrested in Las Vegas for robbing two sports memorabilia collectors at gunpoint in 2007.

Simpson said during trial that he only wanted to take back personal items and family photos that were taken from him after the 1995 acquittal.

He was subsequently convicted of armed robbery in 2008 and sentenced to 33 years in prison, with a minimum of nine years before he was eligible for parole.

Nine years later, Simpson was released from prison in October 2017. 

Simpson played in the NFL for 11 seasons after the Buffalo Bills selected him with the No. 1 overall pick in the 1969 NFL draft. He later played with the San Francisco 49ers.

He won the MVP during his 1973 season, when he rushed for more than 2,000 yards — the first back in NFL history to do so.

Simpson still holds the NFL record for rushing yards per game, a record he set by averaging 143.1 yards per game during the 1973 season.

This report is developing and will be updated with additional information.

Fox News' Paul Best contributed to this report.